Toxic epidermal necrolysis in a patient on atorvastatin therapy expressing human leukocyte antigen alleles

Reactivation of Cytomegalovirus in a Patient with Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse cutaneous reactions to drugs. We describe the case of a 19 year old patient with SJS/TEN overlap syndrome, who developed severe interstitial pneumonia after she had received antiepileptic drugs. A cytomegalovirus infection was diagnosed by Real Time Polymerase Chain Reaction (RT-PCR) detection on Bronchoalveo...

Phenytoin-induced toxic epidermal necrolysis in a neurosurgical patient.

[Toxic epidermal necrolysis].

Toxic epidermal necrolysis is a potentially fatal dermatological disease. Large bullae covering extensive areas of the body cause continuous exfoliation of skin, which requires immediate medical attention. Intraoral manifestations may precede cutaneous lesions. Two cases with different treatment protocols are presented.

Toxic Epidermal Necrolysis

Figure 1. Generalized epidermolysis on anterior and posterior torso with crusty erosions on oral mucosa. DESCRIPTION A 33-year-old woman presents with diffuse rash 3 weeks after completing a course of Bactrim for a urinary tract infection. Erythematous maculopapular rash is evident on the trunk and extremities with painful, epidermal sloughing on the back leaving a moist, denuded dermis. Note t...

Severe Antiretroviral Therapy-Induced Toxic Epidermal Necrolysis in a Child

Toxic epidermal necrolysis (TEN) is a rare and life-threatening condition characterised by extensive epidermal detachment and mucosal erosion. Adverse drug reaction is a strongly correlated causative factor and TEN is currently considered the most severe end of a spectrum of drug-induced mucocutaneous diseases, including Stevens-Johnson syndrome. Attaining an accurate and detailed patient histo...